Maklumat Penyelidikan Saintifik Ke atas Bahan-bahan Yang Terkandung Dalam Jus Delima Bio Emas

Jus Delima Bio Emas ialah sejenis minuman botani atau minuman herba yang diformulasi daripada 7 jenis bahan buahan yang terdiri daripada delima, kurma, zaitun, anggur, aprikot, al manna dan madu lebah serta air RO dan bertapis sebagai bahan asas.

Hendaklah difahami bahawa buahan tersebut bukanlah diambil secara dalam bentuk asalnya sepertimana kebiasaan kita menggunakannya seperti contoh jika buah delima, anggur, zaitun atau aprikot kita ambil isinya untuk dimakan.

Sebenarnya bahagian yang kita makan itu tidak mengandungi bahan-bahan perubatan. Ia hanya mengandungi air, fruktosa dan sedikit zat sahaja.

Bahagian buah yang mengandungi unsur-unsur perubatan yang sangat tinggi terdapat dalam bahagian yang kita tidak makan iaitu dalam kulit, serat atau biji.

Bagi formulasi Jus Delima Bio Emas, bahagian buah yang digunakan ialah:

• Delima – semua bahagian satu biji iaitu kuit, serat, isi dan biji
• Kurma – isi dan biji
• Anggur – biji sahaja
• Zaitun – biji atau daun
• Aprikot – biji sahaja
• Al manna – semua
• Madu – semua

Semua bahagian buahan ini diproses dengan mengambil ekstraknya sahaja untuk dijadikan Jus Delima Bio Emas. Sebab itulah ia dinamakan Jus Delima Bio Emas Minuman Botani (Herba) Campuran.

Jika kita memakan buahan tersebut dalam bentuk buah asal, ia tidak akan memberi manafaat yang tinggi kepada tubuh badan kerana bahagian yang kita makan itu tidak mengandungi unsur-unsur untuk menambahbaik kualiti kesihatan. Sebaliknya bahagian yang penuh dengan nutrien, mineral, vitamin dan bahan kimia semula jadi yang diperlukan untuk kesihatan kita buang kerana tidak sesuai diambil secara oral.

Sebelum menentukan jenis buahan yang digunakan untuk kombinasi dalam Jus Delima Bio Emas, kajian dan penyelidikan telah dijalankan bagi memastikan buahan yang terbaik dan mempunyai unsur-unsur perubatan yang tinggi sahaja dipilih. Rujukan-rujukan kepada journal-journal penyelidikan saintifik dan klinikal oleh pelbagai institusi penyelidikan berwibawa  diserata dunia telah dibuat bagi memastikan keberkesanan setiap satu jenis bahan  itu memenuhi keperluan seperti yang dihajati.

Ada lebih 150 journal penyelidikan bagi 7 bahan yang digunakan dalam Jus Delima Bio Emas dengan melibatkan penyelidik lebih dari 500 orang saintis. Journal-journal ini adalah hasil kerja profesional dengan membentangkan fakta sebenar yang ditemui bagi setiap satu bahan samada ianya berbentuk pro atau kontra bagi memberi pilihan kepada bakal pengguna membuat keputusan setelah mendapat makumat yang tepat.

Kami memutuskan untuk menggunakan bahan-bahan tersebut dalam Jus Delima Bio Emas berdasarkan majoriti keputusan positif hasil penyelidikan bagi setiap jenis bahan.

Berikut ialah journal-journal serta artikel yang memuatkan hasil kajian saintifik dan klinikal ke atas bahan-bahan yang digunakan sebagai formulasi dalam Jus Delima Bio Emas iaitu Ekstrak Delima, Anggur, Zaitun, Kurma, Aprikot, Manna dan Madu.

Maklumat akan dikemaskini dari masa kemasa jika ada penemuan baru.

Sumber rujukan ini diterbitkan oleh National Institute of Health, Amerika Syarikat dan Kanada:

1. Delima

• PEMBERIAN JUS DELIMA MERAH (Punica granatum) DAPAT
  MENINGKATKAN KADAR GLUTATION PEROKSIDASE DARAH
  PADA MENCIT (Mus musculus) DENGAN AKTIVITAS FISIK
  MAKSIMAL
  
• The pomegranate: nature’s power fruit?

• Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing.

• Antioxidant activities of pomegranate fruit extract and its anthocyanidins: delphinidin, cyanidin, and pelargonidin

• Antioxidant and eicosanoid enzyme inhibition properties of pomegranate seed oil and fermented juice flavonoids

• Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer

• Breast cancer chemopreventive properties of pomegranate (Punica granatum) fruit extracts in a mouse mammary organ culture

• Preliminary studies on the anti-angiogenic potential of pomegranate fractions in vitro and in vivo

• Anticancer activities of pomegranate extracts and genistein in human breast cancer cells

• Pomegranate extracts potently suppress proliferation, xenograft growth, and invasion of human prostate cancer cells

• Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel

• Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivo

• Possible synergistic prostate cancer suppression by anatomically discrete pomegranate fractions

• Prostate cancer prevention through pomegranate fruit
• Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer

• Pomegranate polyphenols down-regulate expression of androgen-synthesizing genes in human prostate cancer cells overexpressing the androgen receptor

• Phase-II Study of pomegranate juice for men with prostate cancer and increasing PSA

• Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice.

• Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice

• Cancer chemoprevention through dietary antioxidants: progress and promise

• Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats.

• The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma Caco-2 cells by using the mitochondrial pathway.

• Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells

• Chemopreventive effects of pomegranate seed oil on skin tumor development in CD1 mice

• Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice

• Protective effects of standardized pomegranate (Punica granatum L.) polyphenolic extract in ultraviolet-irradiated human skin fibroblasts

• Photochemopreventive effect of pomegranate fruit extract on UVA-mediated activation of cellular pathways in normal human epidermal keratinocytes

• Differentiation-promoting activity of pomegranate (Punica granatum) fruit extracts in HL-60 human promyelocytic leukemia cells
  

2. Al Manna (Arabic Gum – Acacia Gum)

• Effects of Gum Arabic in rats with adenine-induced chronic renal failure
• Comparative efficacy of three brands of gum acacia on adenine-induced chronic renal failure in ratsEffect of gum arabic on oxidative stress and inflammation in adenine-induced chronic renal failure in rats

• Oxidative stress in uremia: nature, mechanisms, and potential consequences

• Motor and behavioral changes in rats with adenine-induced chronic renal failure: influence of acacia gum treatment

• Effect of Acacia gum on blood pressure in rats with adenine-induced chronic renal failure

• Does treatment with gum Arabic affect experimental chronic renal failure in rats

• Effects of gum arabic (Acacia senegal) on water and electrolyte balance in healthy mice

• The effect of treatment with gum Arabic on gentamicin nephrotoxicity in rats: a preliminary study

• Evaluation of the efficacy of ginger, Arabic gum, and Boswellia in acute and chronic renal failure

• The effects of gum arabic oral treatment on the metabolic profile of chronic renal failure patients under regular haemodialysis in Central Sudan

• Protective effects of oral arabic gum administration on gentamicin-induced nephrotoxicity in rats

3. Kurma

• The fruit of the date palm: its possible use as the best food for the future?
• Date palm kernel extract exhibits antiaging properties and significantly reduces skin wrinkles.
• Therapeutic effects of date palm (Phoenix dactylifera L.) pollen extract on cadmium-induced testicular toxicity.
• Anti-inflammatory and antiproliferative activities of date palm pollen (Phoenix dactylifera) on experimentally-induced atypical prostatic hyperplasia in rats.
• Cross-reactivities between date palm (Phoenix dactylifera L.) polypeptides and foods implicated in the oral allergy syndrome.

4. Aprikot

• Amygdalin Regulates Apoptosis and Adhesion in Hs578T Triple-Negative Breast Cancer Cells
• Hypertension and Wise Therapy
• Reduction of Blood Pressure by Using Apricot Seeds and Vitamin C

• Laetrile/Amygdalin (PDQ®)
• Special Report on Laetrile: The NCI Laetrile Review — Results of the National Cancer Institute’s Retrospective Laetrile Analysis
• Amygdalin delays cell cycle progression and blocks growth of prostate cancer cells in vitro.
• An LC-MS/MS method for the simultaneous determination of amygdalin and paeoniflorin in human urine and application to urinary excretion study
• Amygdalin Blocks Bladder Cancer Cell Growth In Vitro by Diminishing Cyclin A and cdk2
• Amygdalin-mediated inhibition of non-small cell lung cancer cell invasion in vitro
• Antioxidative and Chemopreventive Properties of Vernonia amygdalina and Garcinia biflavonoid
• Amygdalin mediates relieved atherosclerosis in apolipoprotein E deficient mice through the induction of regulatory T cells
• Metabolites of amygdalin under simulated human digestive fluids
• Amygdalin induces apoptosis in human cervical cancer cell line HeLa cells
• Metabolites of amygdalin under simulated human digestive fluids
• Effect of amygdalin on serum proteinic biomarker in pulmonary fibrosis of bleomycin-induced rat
• Advanced research on anti-tumor effects of amygdalin
• Can apricot kernels fatty acids delay the atrophied hepatocytes from progression to fibrosis in dimethylnitrosamine (DMN)-induced liver injury in rats?*
• Anti-inflammatory effect of Prunus armeniaca L. (Apricot) extracts ameliorates TNBS-induced ulcerative colitis in rats*
• Apricot Melanoidins Prevent Oxidative Endothelial Cell Death by Counteracting Mitochondrial Oxidation and Membrane Depolarization*
• Amygdalin Blocks Bladder Cancer Cell Growth In Vitro by Diminishing Cyclin A and cdk2*
• Amygdalin delays cell cycle progression and blocks growth of prostate cancer cells in vitro.
• Amygdalin Influences Bladder Cancer Cell Adhesion and Invasion In Vitro*
• Amygdalin Regulates Apoptosis and Adhesion in Hs578T Triple-Negative Breast Cancer Cells*

5.  Zaitun

• Olive Oil Phenols and Their Potential Effects on Human Health

• Valuable Nutrients and Functional Bioactives in Different Parts of Olive (Olea europaea L.)—A Review

• Factors influencing phenolic compounds in table olives (Olea europaea).

• Olives and olive oil in cancer prevention

• Olive-oil consumption and health: the possible role of antioxidants

• http://www.ncbi.nlm.nih.gov/pubmed/18069902

• Active components and clinical applications of olive oil

• Biological Significance of Seed Oil and Polyphenolic of Olea europaea

6. Anggur

• The effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trials.

• The effectiveness of processed grapefruit-seed extract as an antibacterial agent: II. Mechanism of action and in vitro toxicity

• Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity.

• Grape Seed Extract for Control of Human Enteric Viruses

• Grape seed extract induces cell cycle arrest and apoptosis in human colon carcinoma cells

• The effectiveness of processed grapefruit-seed extract as an antibacterial agent: I. An in vitro agar assay

• Grape seed extract as a potential remineralizing agent: a comparative in vitro study.

• Grape seed and skin extracts inhibit platelet function and release of reactive oxygen intermediates

• Chemoprevention by grape seed extract and genistein in carcinogen-induced mammary cancer in rats is diet dependent

• Grape seed extract (Vitis vinifera) partially reverses high fat diet-induced obesity in C57BL/6J mice

• Polyphenolics in grape seeds-biochemistry and functionality

• Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells.

• Differential effects of grape seed extract against human colorectal cancer cell lines: The intricate role of death receptors and mitochondria.

• Generation of reactive oxygen species by grape seed extract causes irreparable DNA damage leading to G2/M arrest and apoptosis selectively in head and neck squamous cell carcinoma cells.

• View the Evidence: Substances

• Grape seed proanthocyanidin extract inhibits glutamate-induced cell death through inhibition of calcium signals and nitric oxide formation in cultured rat hippocampal neurons

• Consumption of Grape Seed Extract Prevents Amyloid-Beta Deposition and Attenuates Inflammation in Brain of an Alzheimer’s Disease Mouse – PubMed

• Dietary-feeding of Grape Seed Extract Prevents Azoxymethane-induced Colonic Aberrant Crypt Foci Formation in Fischer 344 Rats

• Postprandial blood glucose response to grape seed extract in healthy participants: A pilot study

• Grape seed extract for foodborne virus reduction on produce.

• Grape and grape seed extract capacities at protecting LDL against oxidation generated by Cu2+, AAPH or SIN-1 and at decreasing superoxide THP-1 cell production. A comparison to other extracts or compounds.

• Biological Activities of Polyphenols from Grapes
• Advanced knowledge of three important classes of grape phenolics: anthocyanins, stilbenes and flavonols
• Metabolite profiling of grape: Flavonols and anthocyanins

7. Madu

• Tualang honey improves human corneal epithelial progenitor cell migration and cellular resistance to oxidative stress in vitro.
• Effects of Three Types of Japanese Honey on Full-Thickness Wound in Mice
• Evaluation of the Effects of Honey on Acute-Phase Deep Burn Wounds
• A pre-clinical evaluation of silver, iodine and Manuka honey based dressings in a model of traumatic extremity wounds contaminated with Staphylococcus aureus
• Synergistic antibacterial effect of honey and Herba Ocimi Basilici against some bacterial pathogens.
• Evidence for Clinical Use of Honey in Wound Healing as an Anti-bacterial, Anti-inflammatory Anti-oxidant and Anti-viral Agent: A Review
• Honey as a topical treatment for wounds.
• Antibacterial, antifungal and antioxidant activities of honey collected from Timergara (Dir, Pakistan).
• Post Tonsillectomy Pain: Can Honey Reduce the Analgesic Requirements?
• Stability of Antibiotics in Honey and Sugar Syrup as Affected by Temperature
• Antibacterial action of natural honey on anaerobic bacteroides.