Penggunaan Jus Delima Oleh Pesakit Stenosis Karotid Arteri Mengurangkan Ketebalan Carotidintima-media, Tekanan Darah Dan Pengoksidaan LDL

Penggunaan supplemen yang mengandungi polyphenolic antioxidants kepada haiwan menunjukkan kaitan ke atas perencatan pengoksidaan LDL dan pembentukan sel buih macrophage, dan merencat pengingkatan aterosklerosis. Kami menjalankan kajian kesan penggunaan jus delima (yang kaya dengan tanin dan antosianin) oleh pesakit atherosclerotic dengan stenosis karotid arteri (CAS) mengenai perkembangan luka karotid dan perubahan dalam tekanan oksidatif dan tekanan darah.

Sepuluh pesakit telah diberikan jus delima selama 1 tahun dan lima daripada mereka terus sehingga 3 tahun. Sampel darah telah dikumpul sebelum rawatan dan semasa penggunaan jus delima. Dalam kumpulan kajian yang tidak mengambil jus delima, ketebalan karotid biasa Intima-media (IMT) meningkat sebanyak 9% dalam masa 1 tahun, manakala, penggunaan Jus Delima menyebabkan pengurangan IMT penting, sehingga 30%, selepas 1 tahun.

Aktiviti serum pesakit paraoxonase 1 (PON 1) telah meningkat sebanyak 83%, manakala LDL serum basal oksidatif dan LDL kecenderungan pengoksidaan tembaga ion yang disebabkan kedua-duanya dikurangkan dengan ketara, sebanyak 90% dan 59%, masing-masing, selepas 12 bulan penggunaan Jus Delima, berbanding nilai yang diperoleh sebelum penggunaan Jus Delima.

Tambahan pula, tahap serum antibodi terhadap LDL teroksida telah menurun sebanyak 19%, dan dalam serum selari jumlah status antioksidan (TAS) telah meningkat sebanyak 130% selepas 1 tahun penggunaan Jus Delima. Selepas 1 tahun penggunaan Jus Delima, tekanan darah sistolik telah dikurangkan sebanyak 21% dan terus stabil sepanjang 3 tahun penggunaan selepas 1 tahun penggunaan Jus Delima.

Untuk semua parameter yang dikaji, kesan maksimum diperhatikan selepas 1 tahun penggunaan Jus Delima. Penggunaan berterusan jus delima, sehingga 3 tahun, adalah statik mengenai IMT dan aktiviti serum PON1, manakala serum lipid telah dikurangkan lagi sehingga 16% selepas 3 tahun penggunaan jus delima. Keputusan kajian ini sekali gus mencadangkan bahawa penggunaan Jus Delima  oleh pesakit dengan CAS mengurangkan IMT karotid dan tekanan darah sistolik dan kesan-kesan ini boleh dikaitkan dengan ciri-ciri antioksida polifenol jus delima.

Artikel Asal:

Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation

Abstract

Dietary supplementation with polyphenolic antioxidants to animals was shown to be associated with inhibition of LDL oxidation and macrophage foam cell formation, and attenuation of atherosclerosis development.

We investigated the effects of pomegranate juice (PJ, which contains potent tannins and anthocyanins) consumption by atherosclerotic patients with carotid artery stenosis (CAS) on the progression of carotid lesions and changes in oxidative stress and blood pressure.

Ten patients were supplemented with PJ for 1 year and five of them continued for up to 3 years. Blood samples were collected before treatment and during PJ consumption. In the control group that did not consume PJ, common carotid intima-media thickness (IMT) increased by 9% during 1 year, whereas, PJ consumption resulted in a significant IMT reduction, by up to 30%, after 1 year. The patients’ serum paraoxonase 1 (PON 1) activity was increased by 83%, whereas serum LDL basal oxidative state and LDL susceptibility to copper ion-induced oxidation were both significantly reduced, by 90% and 59%, respectively, after 12 months of PJ consumption, compared to values obtained before PJ consumption. Furthermore, serum levels of antibodies against oxidized LDL were decreased by 19%, and in parallel serum total antioxidant status (TAS) was increased by 130% after 1 year of PJ consumption. Systolic blood pressure was reduced after 1 year of PJ consumption by 21% and was not further reduced along 3 years of PJ consumption. For all studied parameters, the maximal effects were observed after 1 year of PJ consumption. Further consumption of PJ, for up to 3 years, had no additional beneficial effects on IMT and serum PON1 activity, whereas serum lipid peroxidation was further reduced by up to 16% after 3 years of PJ consumption.

The results of the present study thus suggest that PJ consumption by patients with CAS decreases carotid IMT and systolic blood pressure and these effects could be related to the potent antioxidant characteristics of PJ polyphenols.

Link: http://www.clinicalnutritionjournal.com/article/S0261-5614(03)00213-9/abstract