Kesan Pengambilan Suplemen Delima Keatas Ekspresi gen GLUT-4 Dan Kawalan Glisemik Pada Pesakit Kencing Manis Yang Gemuk – A Randomized Controlled Clinical Trial

Punca utama penyakit kencing manis jenis 2 ( jenis yang biasa berlaku berlaku di Malaysia) ialah disebabkan kes kegagalan transporter  glukosa jenis 4 (GLUT-4) dan rembesan insulin berfungsi secara normal.

Pada masa ini kesan negatif ubat-ubatan antidiabetik yang ketara keatas pesakit yang menggunakannya telah mendorong saintis melakukan penyelidikan keatas potensi  ubatan nutraseutikal (herba) sebagai alternatif.

Satu pasukan saintis pengkaji seramai 8 orang daripada University of Medical Sciences, Iran di ketuai oleh Khajebishak Y telah menjalankan penyelidikan dan kajian mengenai keberkesanan suplemen minyak biji delima bagi mengatasi kegagalan transporter  glukosa jenis 4 (GLUT-4) dan rembesan insulin berfungsi secara normal.

Kajian randomized clinical ini dilakukan pada tahun 2018 keatas sejumlah 52 pesakit kencing manis selama 8 minggu di Tabriz, Iran. Pesakit dibahagi kepada 2 kumpulan dimana kumpulan pertama seramai 26 pesakit diberi 3 kapsul setiap hari yang mengandungi 1gm minyak buah delima (PSO) manakala kumpulan plasebo (n = 26; jumlah yang sama paraffin).

Hasil kajian klinikal ini mendapati Ekspresi gen GLUT-4 telah meningkat dengan ketara dalam kumpulan pesakit yang mengambil minyak buah delima (PSO) dan kandungan gula darah menurun. Kesimpulan yang dihasilkan dari randomized controlled clinical trial  ini telah membuktikan bahawa  minyak buah delima (PSO) berjaya meningkatkan ekspresi gen GLUT-4 pada pesakit diabetes tanpa apa-apa kesan sampingan.

Sesungguhnya ubatan dari herba  seperti buah delima memberi manafaat yang sangat besar dalam merawat dan mencegah penyakit kronik seperti kencing manis dan lain-lain dan daripada kepitusan pelbagai peringkat kajian mendapati buah delima tidak mendatangkan kesan sampingan.

Terdapat 24 journal kajian lain berhubung kebaikan buah delima keatas penyembuhan kencing manis. Journal tersebut boleh diakses seperti di bawah:

Sumber: https://www.ncbi.nlm.nih.gov/pubmed/30945297

Journal Kajian Hubungkait Buah Delima Digunakan Untuk Rawatan Kencing Manis Jenis 2

1. Could Pomegranate Juice Help in the Control of Inflammatory Diseases?
2. Pomegranate and type 2 diabetes
3. Effects of pomegranate juice consumption on oxidative stress in patients with type 2 diabetes: a single-blind, randomized clinical trial
4. Lack of efficacy of pomegranate supplementation for glucose management, insulin levels and sensitivity: evidence from a systematic review and meta-analysis
5. Effects of Pomegranate Seed Oil on Metabolic State of Patients with Type 2 Diabetes Mellitus
6. Polyphenols and Glycemic Control
7. Pomegranate (Punicagranatum) juice decreases lipid peroxidation, but has no effect on plasma advanced glycated end-products in adults with type 2 diabetes: a randomized double-blind clinical trial.
8. Effects of Concentrated Pomegranate Juice on Subclinical Inflammation and Cardiometabolic Risk Factors for Type 2 Diabetes: A Quasi-Experimental Study.
9. Effects of pomegranate juice consumption on inflammatory markers in patients with type 2 diabetes: A randomized, placebo-controlled trial
10. Pomegranate: a fruit that ameliorates metabolic syndrome
11. Effects of pomegranate juice consumption on blood pressure and lipid profile in patients with type 2 diabetes: A single-blind randomized clinical trial.
12. Punica granatum: heuristic treatment for diabetes mellitus
13. Paraoxonase 1 (PON1) and pomegranate influence circadian gene expression and period length
14. Pomegranate as a functional food and nutraceutical source
15. Pomegranate juice: a heart-healthy fruit juice
16. Pomegranate polyphenols lower lipid peroxidation in adults with type 2 diabetes but have no effects in healthy volunteers: a pilot study.
17. Fresh pomegranate juice ameliorates insulin resistance, enhances β-cell function, and decreases fasting serum glucose in type 2 diabetic patients
18. The effects of pomegranate juice consumption on blood pressure and cardiovascular health
19. Extracts of black bean peel and pomegranate peel ameliorate oxidative stress-induced hyperglycemia in mice.
20. A Traditional Mouthwash (Punica granatum var pleniflora) for Controlling Gingivitis of Diabetic Patients: A Double-Blind Randomized Controlled Clinical Trial.
21. Dietary Polyphenols and Periodontitis-A Mini-Review of Literature.
22. The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats
23. Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia
24. Anti-oxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages